Deafness
Conditions
Interventions
Observation group:None
Sponsors
Eye & ENT Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
No minimum to 65 Years
Inclusion criteria
Inclusion criteria: 1. Have a clinically confirmed diagnosis of hearing loss (conductive, sensorineural, or mixed deafness) 2. Subjects or their legally authorized representatives voluntarily participate and provide written informed consent using the appropriate version of the consent form 3. Agree to the collection of clinical data and a minimum necessary volume of biospecimens, and consent to undergo genetic testing and necessary familial segregation analysis (subject to additional specific consent)
Exclusion criteria
Exclusion criteria: 1. Individuals with an established non-genetic etiology for their hearing loss, including but not limited to: birth asphyxia, prenatal infection history, neonatal hyperbilirubinemia, viral infections, bacterial meningitis, labyrinthitis, trauma-induced hearing loss, autoimmune inner ear disease, otitis media, hearing loss due to tumors of the internal auditory canal or cerebellopontine angle, ototoxicity from chemotherapeutic agents (e.g., cisplatin), noise-induced hearing loss, and presbycusis 2. Any candidate whom the investigator deems unsuitable for participation in the study (e.g., due to an inability to provide consent or comply with the follow-up schedule)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pathogenic/likely pathogenic variants;Phenotype; | — |
Countries
China
Contacts
Public ContactYilai Shu
Eye & ENT Hospital of Fudan University
Outcome results
None listed