Male infertility
Conditions
Interventions
Gold Standard:Clinical Diagnosis of Male Fertility and Infertility
Index test:The fluorescence intensity and localization ratio data of 5 male infertility target molecules on sperm.
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Basic requirements: 1. Both men and women were 20-40 years old; 2. Abstinence for 2-7 days; No alcohol abuse within 2 weeks; Control group requirements: 1. The sample of natural conception requires that the wife has been pregnant for 3 months or more, or the child has been born within 2 months; 2. Sperm bank samples are required to have a storage number; 3.IVF samples were required to successfully obtain at least one fertilized egg. Case group requirements: 1. Have a history of infertility for more than one year; 2. Semen routine results met the requirements of "WHO Laboratory Manual for the examination and processing of Human semen" (2010 edition) on sperm number and motility; 3. In case group A, the women were required to obtain at least one fertilized egg after ICSI if the six tests were normal or IVF failed. 4.For cases B, C and D, the women were required to have normal six tests or to have successfully obtained at least one fertilized egg after ICSI.
Exclusion criteria
Exclusion criteria: Basic exclusion criteria: 1. Those who do not meet the inclusion criteria; 2. Patients with diseases that the clinical establishment (physician) considers inappropriate for participation in the trial. Control group: Samples conceived naturally with assisted reproductive technology were excluded. Case group: Patients with the following clear causes of male infertility were excluded: patients with small testes, patients with previous testicular trauma, patients with radiotherapy or chemotherapy after surgery for malignant tumors, patients with severe varicocele, patients with cryptorchidism, hematospermia, and leukocytospermia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fluorescence intensity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Localization rate; | — |
Countries
China
Contacts
Public ContactHui Jiang
Peking University Third Hospital
Outcome results
None listed