Major Depressive Disorder
Conditions
Interventions
Experimental Group:One-time bilateral hippocampal theta frequency TUS stimulation was performed using individualized acoustic models and MRI navigation systems
Pseudo-stimulus group:One-time bilateral hippocampal theta frequency sham stimulation was performed using individualized acoustic models and MRI navigation systems
Sponsors
Shandong Daizhuang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for depression set by ICD-10; 2. Age: 18 years old and above, 55 years old and below, gender not limited. 3. The patient voluntarily participates in the study, obtains the consent of the family members, and signs the informed consent form; 4. Understand written language and be capable of conducting questionnaire surveys.
Exclusion criteria
Exclusion criteria: 1. Have a history of substance dependence; Have brain trauma, epilepsy or other organic brain diseases; 2. Those with severe heart, liver or kidney insufficiency, metabolic diseases and other serious physical illnesses; 3. Contraindications for TUS or magnetic resonance imaging scans: such as those with pacemakers, metal foreign bodies in the body, braces, and clautrophobia. 4. Intracranial implants (such as aneurysm clips, shunt devices, stimulators, cochlear implants or electrodes) or any other metal objects inside or near the head cannot be safely removed. 5. Any neurological disorders or serious physical diseases. 6. History of electroconvulsive therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fMRI Resting-state Functional Connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Emotional and cognitive responses; | — |
Countries
China
Contacts
Public ContactKun Li
Shandong Daizhuang Hospital
Outcome results
None listed