Perioperative Neurocognitive Disorders
Conditions
Interventions
Insulin nasal drop group (Group I): Each patient in Group I will receive intranasal ASP-I (40 IU per dose, prepared by diluting 0.4 ml of ASP-I with an equal volume of saline to a total volume of 0.8
Placebo control group (P group):Each patient in Group P will receive same volume of saline, with all other procedures identical to those in Group I
Sponsors
The Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Intended for elderly patients aged >=60 undergoing non-cardiac surgery under general anesthesia, including patients undergoing general anesthesia for gastrointestinal surgery, thoracic surgery, urological surgery, orthopedic surgery, gynecological surgery, etc.; 2. Signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Contraindications for intranasal administration (such as nasal defects or lesions); 2. History of insulin allergy; 3. Severe communication disorders (such as coma, severe dementia, speech disorders, severe visual or hearing impairments, etc.); 4. Presence of severe heart, liver, or kidney diseases (such as severe arrhythmia, symptomatic coronary artery disease, myocardial ischemia/infarction, heart failure [NYHA III-IV], liver dysfunction [Child-Pugh B/C], or renal dysfunction [eGFR <30 mL/min/1.73m^2]); 5. History of mental illness; 6. Individuals with significant cooperation difficulties (e.g., very low educational level, unable to read or perform basic arithmetic); 7. Diabetic patients; 8. Individuals planning to undergo neurosurgical intracranial procedures;9. History of substance abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative acute delirium/agitation;Duration of POD;Delayed neurocognitive recovery;Postoperative neurocognitive disorders;Instrumental activities of daily living (ADLs);Sleep quality; | — |
Countries
China
Contacts
Public ContactZhang Lei
The Affiliated Hospital of Qingdao University
Outcome results
None listed