Recurrent pregnancy loss
Conditions
Interventions
High risk of folate metabolism :None
Non-high risk of folate metabolism:None
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Patients with recurrent pregnancy loss in the Department of reproductive immunology of our hospital will be selected. Inclusion criteria: 1. Age 20-40 years old, non pregnant state, number of pregnancy loss >= 2; 2. Both spouses' chromosomes are normal; 3. The semen routine examinations of the men are normal; 4. The patients will be informed of the contents of the study, voluntarily participat in and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Suffering from cardiovascular, cerebrovascular, liver and kidney, hematopoietic system diseases or systemic or mental diseases; 2. Recent use of immune or anticoagulant agents or other drugs that affect the experimental results. 3. The patients with autoimmune diseases, such as SLE.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene MTHFR C677T;Lymphocyte subsets;Th1/Th2 cytokines;HCY; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vitamin B12;Vitamin D ; | — |
Countries
China
Contacts
Public ContactNa Yu
Shanghai First Maternity and Infant Hospital
Outcome results
None listed