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Comparison of the effect of cyclosporine and sevoflurane combined with remifentanil TCI on postoperative recovery quality (QoR-40 score) in female patients with thyroid cancer : A multicenter, randomized, controlled study

Comparison of the effect of cyclosporine and sevoflurane combined with remifentanil TCI on postoperative recovery quality (QoR-40 score) in female patients with thyroid cancer : A multicenter, randomized, controlled study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500110488
Enrollment
Unknown
Registered
2025-10-14
Start date
2025-10-20
Completion date
Unknown
Last updated
2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid tumor

Interventions

TIVA group:Cyclophenol
Inhalation group:sevoflurane

Sponsors

Xianyang Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-65 years old; 2. Female patients with >=1h and <=4h of surgery, elective general anesthesia to descend thyroid gland lobe or total resection + lymph node dissection; 3. ASA score is grade I or II; 4.18 kg/m^2<BMI<30 kg/m^2 Clearly understood, voluntarily participated in the study, and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with thyroid tumors with an operation time of 4 hours, requiring simple adenolobectomy or complex surgery; 2. ASA score of grade III or above; 3. Patients who are taking any sedatives, opioids or sleep aids; 4. Obese patients with BMI >=30 kg/m^2, pregnant or lactating patients; 5. Allergic or contraindicated to the above-mentioned test drugs such as cyclopol, opioids, remifentanil, etc.; 6. Patients who have participated in other drug clinical trials as subjects in the past 3 months are not suitable for this trial in the opinion of the investigator.

Design outcomes

Primary

MeasureTime frame
QoR-40 of POD1;

Secondary

MeasureTime frame
Postoperative hospitalization time;Blood pressure, heart rate SpO2;Dosage of antiemetic and analgesic agents used;PACU dwell time;Injection pain and incidence of PONV;Hypotension incidence rate;Cortisol and noradrenaline levels in the blood;Total amount of remifentanil;Decannulation time;RS rating;QoR-40 before surgery and POD2;

Countries

China

Contacts

Public ContactWang Yu

Xianyang Central Hospital

wy13991012233@163.com+86 139 9101 2233

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026