diabetic kidney disease
Conditions
Interventions
Low-intensity pulsed ultrasound treatment group:Low-intensity pulsed ultrasound stimulation
Sponsors
Jiangsu Province Hospital and The First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years and =9.0%. 3. Estimated glomerular filtration rate (eGFR) calculated using the CKD-EPI formula must be >=30 and =200 mg/g and <=5000 mg/g. 5. Treatment with the maximum tolerated dose of an ACE inhibitor or ARB for at least 4 weeks, with no change in dosage during this period; or not using such treatment due to contraindications. 6. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Active bacterial or viral infection; 2. Pregnant women; 3. Presence of other non-diabetic kidney diseases, such as autosomal dominant/recessive polycystic kidney disease, lupus nephritis, ANCA-associated nephritis, etc. (excluding non-obstructive nephrolithiasis); 4.ALT or AST levels >=3 times the upper limit of normal; 5. Complicated by decompensated liver cirrhosis or hypersplenism; 6. Participants with type 1 diabetes; 7. Use of corticosteroids or immunosuppressants for kidney disease within the past 6 months; 8. NYHA Class IV heart failure within the past 3 months; 9. Newly diagnosed unstable angina or cerebrovascular event within the past 3 months; 10. Blood pressure below 90/60 mmHg or above 180/100 mmHg within the past 2 weeks; 11. Other conditions deemed inappropriate by the investigator, such as clinical instability in overall, metabolic, or cardiovascular health; 12. Participation in other clinical trials within 4 weeks prior to the start of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urine Albumin-to-Creatinine Ratio;24-hour Urinary Protein Excretion;Percentage change in eGFR from baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in inflammatory markers; | — |
Countries
China
Contacts
Public ContactHuijuan Mao, Xiangqing Kong
Jiangsu Province Hospital and The First Affiliated Hospital with Nanjing Medical University
Outcome results
None listed