Postoperative pain
Conditions
Interventions
Morphine Group:Postoperative analgesia was administered via a patient-controlled intravenous analgesia (PCIA) regimen. A 0.9% sodium chloride solution (45 mL) served as the diluent for morphine (1 mL:
Tegileridine Group:Postoperative analgesia was administered via a patient-controlled intravenous analgesia (PCIA) regimen. A 0.9% sodium chloride solution (45 mL) served as the diluent for tegileridin
Sponsors
Zhengzhou Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Age >>= 65 years, ASA 2-3 classification, BMI 18.5-30 kg/m^2, elective laparoscopic abdominal tumour surgery (hepatobiliary, gastrointestinal)
Exclusion criteria
Exclusion criteria: Severe cardiac insufficiency (NYHA Class III-IV), severe hepatic dysfunction (Child-Pugh Class C), renal impairment (undergoing dialysis preoperatively), pregnancy or lactation, history of allergy to study medication, chronic pain or preoperative analgesic use, administration of medications potentially affecting analgesic response (anticonvulsants, antidepressants or antipsychotics), psychiatric or neurological disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of moderate to severe pain during physical activity within 24 hours post-surgery (moderate to severe pain defined as NRS pain score >=4); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of moderate to severe pain at rest within 24 hours post-surgery;Rate of rescue analgesia within 24 hours post-surgery;Number of PCIA compressions within 24 hours post-surgery;Pain satisfaction score at 24 hours post-surgery (assessed using the NRS scale, 0–10 points, where a higher score indicates greater satisfaction);Time of first ambulation;time to first flatus; | — |
Countries
China
Contacts
Public ContactGuanyu Yang
Zhengzhou Central Hospital
Outcome results
None listed