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A prospective, multicenter study evaluating the consistency of drug sensitivity assessments in glioblastoma organoids derived from both tumor and blood tissues

A prospective, multicenter study evaluating the consistency of drug sensitivity assessments in glioblastoma organoids derived from both tumor and blood tissues

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500110476
Enrollment
Unknown
Registered
2025-10-14
Start date
2025-10-20
Completion date
Unknown
Last updated
2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glioblastoma

Interventions

Observation group:None

Sponsors

Tangdu Hospital,Fourth Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 18–65 years, regardless of gender; 2. Diagnosed with glioblastoma by clinical and radiological methods; 3. Patients with glioblastoma planned for craniotomy and resection; 4. Patients comply with the conventional postoperative treatment plan for gliomas; 5. Patients voluntarily participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1.Underwent preoperative radiochemotherapy; 2.Have severe cardiovascular or circulatory system diseases and are unable to tolerate surgery; 3.Participated in other investigational drug or device clinical trials within the past month; 4.Unable to understand the requirements of the trial or unable to complete the study follow-up plan; 5.Pregnant or breastfeeding women; 6.Patients who cannot complete the follow-up due to mental illness, cognitive disorders, or emotional disorders; 7.Subjects who are deemed unsuitable for participation in the study by the investigator.

Design outcomes

Primary

MeasureTime frame
Evaluate the proportion of successful organoid models established from blood and tissue samples.;

Secondary

MeasureTime frame
Evaluation the consistency of drug sensitivity between blood and tumor tissue organoids;

Countries

China

Contacts

Public ContactLiang Wang

Tangdu Hospital,Fourth Military Medical University

doctorwangliang@163.com+86 133 1923 2049

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026