Postoperative delirium
Conditions
Interventions
The dexmedetomidine group ( D group, n=126 cases).:Based on the standard anesthetic protocol, dexmedetomidine was continuously infused at a rate of 0.6 µg·kg-1·h-1 during both the induction and mainte
Placebo control group (C group,n=126 cases) :Based on the standard anesthetic protocol, a volume-matched continuous infusion of normal saline was administered intravenously during the induction and ma
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1)Patients classified as ASA (American Society of Anesthesiologists) physical status III or below, diagnosed by neurosurgery as meeting the indications for mechanical thrombectomy and undergoing the procedure. (2)Normal preoperative coagulation and platelet function tests. (3)No use of analgesics or sedatives within 1 day before surgery. (4)No allergy to the anesthetics or contrast agents used in this study. (5)Age >= 18 years. (6)The patient or their legal guardian consents to blood sampling and signs the informed consent form.
Exclusion criteria
Exclusion criteria: (1)Patients with neurological or psychiatric disorders; (2)Patients taking medications that affect the nervous or psychiatric systems; (3)Patients with irreversible brainstem injury; (4)Patients with severe cardiac, pulmonary, cerebral, hepatic, or renal diseases; (5)Patients with allergies to the drugs or materials used in this study; (6)Patients or their legal guardians refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| The severity of postoperative delirium;tau-PT217;NSE; | — |
Countries
China
Contacts
Public ContactJi Shi
The First Hospital of Hebei Medical University
Outcome results
None listed