Ischemic Stroke
Conditions
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-79 years old 2. Meet the diagnosis of acute ischemic stroke; 3. mRS 0-1 points before the onset of the disease; 4. Baseline NIHSS score >=6 points; 5. Have a clear onset time and within 12 hours; 6. Preoperative multimodal CT imaging examination, including head CT plain scan, head CTP and head CTA; 7. Imaging criteria: CTP: 0ml15ml, mismatch rate >1.8; CTA: The blood vessel responsible for symptoms is proximal occlusion of the middle cerebral artery M1 and suggests embolic lesion (defined as the M1 segment is bounded by the origination site of the striated artery and occluded proximally); 8. Baseline infarct growth rate (IGR1) = 5ml/h (IGR1=baseline CTP core (ml)/onset to baseline CTP time (ml/h); 9. Ultrasound stimulation can be started within 15 minutes after imaging examination; 10. Planned endovascular treatment and eTICI grade 2c or 3 recanalization; 11. Patients or their families sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. Intravenous thrombolysis of drugs; 2. Imaging suggests in situ chronic stenosis or extracranial stenosis tandem lesions; 3. History of cerebral infarction and TIA within 3 months; 4. Previous history of cerebral hemorrhage, brain tumor, or cerebrovascular malformation; 5. Presence of life-threatening diseases within 6 months that cannot be evaluated for 3 months; 6. Pregnant women, mental illness, severe liver and kidney insufficiency, severe heart failure; 7. Concurrent participation in another clinical drug or device intervention study; 8. Other situations that the investigator considers unsuitable for participating in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-intervention infarct growth rate;Infarct growth volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS score;mRS score; | — |
Countries
China
Contacts
Public ContactZheng Yuanyi
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed