Acute Lymphoblastic Leukemia
Conditions
Interventions
Observational Group:None
Sponsors
Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
8 Years to 21 Years
Inclusion criteria
Inclusion criteria: 1.Age: Patients must be >=8 years old and <21 years old at enrollment. 2. Diagnosis: ALL-LR patients who are assigned to Group AB during randomization and have been in maintenance therapy or completed treatment within 2 years with remission status. 3.Previous Treatment: Received treatment under the CCCG-ALL2020 protocol. 4.Physical Condition: Able to complete neuropsychological assessment and MRI examination. 5. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with neurodevelopmental disorders unrelated to the primary disease (e.g., Down syndrome, Fragile X syndrome, autism spectrum disorder, epilepsy). Note: Hyperactivity disorder or specific learning disabilities (e.g., dyslexia) should not be excluded. 2. Patients with significant sensory impairments (e.g., uncorrectable visual impairment or hearing loss). 3. Recurrent cases or second tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-reported subjective cognitive concerns assessment (PROMIS Pediatric Cognitive Function Short Form); | — |
Secondary
| Measure | Time frame |
|---|---|
| Performance-based cognitive function screening;MRI report; | — |
Countries
China
Contacts
Public ContactCai Jiaoyang
Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed