Heart failure with preserved ejection fraction
Conditions
Interventions
Uric acid-lowering group:Febuxostat+Standard therapies for HFpEF
Control group:Standard therapies for HFpEF
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1 Patients with chronic HFpEF who are over 18 and less than 85 years old, classified as NYHA grade II-III. Diagnostic criteria for HFpEF: The patient has typical symptoms and signs of heart failure, with normal or only slightly decreased LVEF (>=50%), and evidence of elevated left ventricular filling pressure (such as E/e '>8, elevated BNP and/or increased left atrial volume, etc.). 2 Hyperuricemia (UA>420umol/L in the past 3 months, if uric acid-lowering drugs were used before enrollment, the serum uric acid value should be rechecked ten days after drug withdrawal. Only those who meet the above criteria can be enrolled. 3 Participate voluntarily and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1 Gouty arthritis and kidney stones. 2 Severe liver dysfunction (aspartate aminotransferase and alanine aminotransferase > 3×ULN, total bilirubin > 2×ULN). 3 Severe renal insufficiency (eGFR<30ml/min/1.73m^2). 4 Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite endpoints (all-cause mortality, heart failure rehospitalization); | — |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction;E/e’;Serum uric acid level; | — |
Countries
China
Contacts
Public ContactJun Gu
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed