Hypertension
Conditions
Interventions
Ciprofol Group:Ciprofol Group: Ciprofol Injection was administered via intravenous bolus under routine anesthetic monitoring.
Initial dose: Ciprofol 0.4–0.5 mg/kg, plus Sufentanil 0.1 µg/kg
Maintenanc
Propofol Group:Propofol Group: Propofol Injection was administered via intravenous bolus.
Initial dose: Propofol 1.5–2.0 mg/kg, plus Sufentanil 0.1 µg/kg
Maintenance dose: Additional Propofol 0.5–1.0
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Outpatient or inpatient patients aged 18–75 years (2) Patients with clearly diagnosed primary hypertension (Grade I–II, stably controlled) (3) Patients scheduled to undergo painless gastrointestinal endoscopy (4) Patients with an ASA physical status classification of Grade I–III (5) Patients who have signed the informed consent form
Exclusion criteria
Exclusion criteria: (1) Severe cardiopulmonary dysfunction (e.g., heart failure, COPD of Grade III or above) (2) Grade III hypertension or poorly controlled blood pressure (SBP > 180 mmHg or DBP > 110 mmHg) (3) Severe hepatic or renal dysfunction (4) A history of allergy to sedatives or anesthetic drugs (5) Patients with mental illness or those unable to cooperate (6) Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic Blood Pressure(SBP);Diastolic Blood Pressure(DBP);Mean Arterial Pressure (MAP);SpO2;heart rate;Incidence of Adverse Reactions; | — |
Countries
China
Contacts
Public ContactLu Yan
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed