Cognitive dysfunction following hip fracture surgery
Conditions
Interventions
Group P:Phenylephrine was used during operation
Group N:Norepinephrine was used during operation
Sponsors
Lu'an Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion Criteria Elderly patients scheduled for elective hip fracture surgery who voluntarily participate in this trial after providing written informed consent (from both the patient and their legal guardian); 2.Age >= 65 years; 3.American Society of Anesthesiologists (ASA) physical status classification I-III; 4.No severe visual/auditory impairments that would hinder normal communication; 5.Preoperative use of the Montreal Cognitive Assessment Basic (MoCA-B) to ensure the absence of cognitive impairment and the ability to complete cognitive function tests prior to surgery.
Exclusion criteria
Exclusion criteria: 1.Exclusion Criteria Patient refusal or inability to cooperate with neuraxial anesthesia (e.g., spinal/epidural anesthesia). Poorly controlled hypertension preoperatively (SBP >= 180 mmHg or DBP >= 110 mmHg). Preoperative hypotension (SBP <90 mmHg or MAP <60 mmHg). Severe cardiac conditions, including: Significant arrhythmias Valvular stenosis Severe intracardiac shunting Impaired cardiac function Intraoperative acute cardiovascular events (e.g., severe hypotension, myocardial ischemia, or arrhythmia requiring intervention). Emergency surgery or concurrent participation in another clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium within 3 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamic data;Intraoperative regional cerebral oxygen saturation (rSO2) data;Postoperative VAS (Visual Analogue Scale) score;Renal function;Dosage of vasoactive drugs;Intraoperative adverse events;Arterial Blood Gas Analysis;Quality of Recovery-15 scale (QoR-15);Others;Baseline patient characteristics;Confusion Assessment Method-Revised;Postoperative adverse events; | — |
Countries
China
Contacts
Public ContactMa Qigang
Lu'an Hospital of Traditional Chinese Medicine
Outcome results
None listed