Sepsis-Associated Thrombocytopenia
Conditions
Interventions
No Platelet Transfusion Group:None
Platelet Transfusion Group:None
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients admitted to the ICU between January 2021 and May 2024 and subsequently discharged; 2. Age >= 18 years; 3. Meeting the Sepsis-3.0 diagnostic criteria; 4. Platelet count = 48 hours;
Exclusion criteria
Exclusion criteria: 1. Active bleeding (e.g., major gastrointestinal bleeding, intracranial hemorrhage) or hematologic malignancies (e.g., leukemia, myelodysplastic syndrome, lymphoma); 2. Liver cirrhosis (Child-Pugh class B/C), chronic kidney disease (CKD stage 4-5), or autoimmune diseases (e.g., systemic lupus erythematosus); 3. Receipt of chemotherapy, immunosuppressants (e.g., cyclosporine, rituximab), or hematopoietic stem cell/solid organ transplantation within 2 weeks; 4. Pregnancy or lactation; 5. Pre-existing chronic thrombocytopenia (baseline platelet count 1 month) or long-term use of antiplatelet/anticoagulant drugs (>2 weeks); 6. Significant baseline coagulation dysfunction at ICU admission:Prothrombin time (PT) >1.5 times the upper limit of normal; Activated partial thromboplastin time (APTT) >1.5 times the upper limit of normal; Fibrinogen level 20% of key data (e.g., daily platelet counts, ICU survival status within 28 days).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ICU mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory indicator-related endpoints;Bleeding events;Thrombotic events;ICU length of stay within 28 days;Platelet transfusion therapy-related endpoints; | — |
Countries
China
Contacts
Public ContactZhenhua Zeng
Southern Medical University Southern Hospital
Outcome results
None listed