Postoperative recovery quality
Conditions
Interventions
Remazolam group (Group R):During anesthesia induction, remimazolam is administered intravenously at a dose of 0.2-0.3 mg/kg
for anesthesia maintenance, remimazolam is infused intravenously via a pump at a rate of 1.0-2.0 mg/kg/h.
Propofol group (Group P):During anesthesia induction, propofol is administered intravenously at a dose of 1.5-2.0 mg/kg
for anesthesia maintenance, propofol is infused intravenously via a pump at a rate of 4.0-10.0 mg/kg/h.
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Voluntarily participate in this study and sign an informed consent form; 2.Age 18-65 years old, gender unrestricted, body mass index (BMI) 18-30 kg/m^2; 3.ASA I-III grade; 4.Intending to undergo endoscopic upper gastrointestinal mucosal resection procedures (e.g., esophageal ESD, gastric ESD, etc.), with an estimated operation time >=30 minutes.
Exclusion criteria
Exclusion criteria: Patients will be excluded if they meet any of the following criteria: 1. Pregnant or breastfeeding women, or those planning pregnancy within three months; 2. Contraindications or hypersensitivity to benzodiazepines, propofol, opioids, or their components; 3. Preoperative respiratory/circulatory dysfunction (e.g., acute upper respiratory infection, asthma exacerbation, acute exacerbation of chronic obstructive pulmonary disease, respiratory failure, uncontrolled severe hypertension, heart failure); 4. Severe hepatic impairment (Child-Pugh Class C) or severe renal failure (requiring dialysis); 5. History of mental illness, cognitive impairment, or inability to complete questionnaire assessment; 6. Long-term use of sedatives, anti-anxiety medications, or opioid analgesics; 7. Participation in other clinical trials within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of recovery-15 (QoR-15) score on postoperative day 1; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of recovery-15 (QoR-15) scores on postoperative day 3 and Postoperative day 7;Incidence of hypotension;Sleep status on postoperative day 1, day 3, and day 7;Anxiety and depression scores on postoperative day 1, day 3, and day 7;Pain score and severity within 24 hours postoperatively;Incidence and severity of PONV within 24 hours postoperatively;The severity of cough during the awakening period;Satisfaction scores of endoscopists and patients regarding the surgical experience;Incidence of perioperative adverse events;Total Perioperative Dose of Anesthetic and Vasoactive Agents; | — |
Countries
China
Contacts
Public ContactXing Na
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed