cholecystolithiasis
Conditions
Interventions
Control group:cyclopolyphenol
Test group:cyclopolyphenol combined with dexmedetomidine
Sponsors
Peking University Shougang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65, with no gender restrictions; 2. Body Mass Index (BMI) 18-30 Kg/m²; 3. Anesthesia risk classification of Level I and Level II by the American Society of Anesthesiologists; 4. Undergo laparoscopic cholecystectomy with stone removal under general anesthesia at a later date; 5. Non-acute inpatients who have undergone appropriate preoperative preparation; 6. Vital signs: respiratory rate >=10 and =95% when breathing air; systolic blood pressure (SBP) >=90mmHg and =60mmHg and =55 and <=100 beats per minute; 7. Able to understand the research process and methodology, voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those with contraindications to general anesthesia or a history of anesthesia accidents; 2. Known or suspected allergies or contraindications to Cisapride Injection, excipients, benzodiazepines, opioids, muscle relaxants, etc; 3. Patients with combined cranial brain injury, intracranial hypertension, stroke, unstable angina pectoris, and myocardial infarction; 4. Respiratory insufficiency, obstructive lung disease, presence of a difficult airway, or being assessed as having difficulty with tracheal intubation (Modified Mallampati grade III or IV); 5. Uncontrolled diabetes or hypertension; 6. Severe liver dysfunction or severe renal insufficiency; 7. History of alcohol abuse or drug dependence; 8. Abuse or long-term use of anesthetic, sedative, or analgesic drugs; 9. Those with a history of mental illness; 10. Participants who have participated in any drug clinical trial within the previous month; 11. Pregnant and lactating women; women or men who are capable of reproduction and are unwilling to use contraception throughout the trial period; subjects (including male subjects) who plan to become pregnant within 1 month after the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Mini-Mental State Examination;Hamilton Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index Assessment Form;Wake-up time;nausea and vomiting;dizziness;Extubation time;Respiratory depression;VAS; | — |
Countries
China
Contacts
Public ContactYilei Zhang
Peking University Shougang Hospital
Outcome results
None listed