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Study on the Impact of Intra-Individual Variability in Imatinib Concentration on Clinical Outcomes in Patients with Gastrointestinal Stromal Tumors

Study on the Impact of Intra-Individual Variability in Imatinib Concentration on Clinical Outcomes in Patients with Gastrointestinal Stromal Tumors

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500110391
Enrollment
Unknown
Registered
2025-10-13
Start date
2025-10-14
Completion date
Unknown
Last updated
2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal stromal tumors (GIST)

Interventions

Gastrointestinal stromal tumor patient group:None

Sponsors

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age>=18 years old; 2.The diagnosis of gastrointestinal stromal tumor was confirmed through pathological analysis and imaging examinations; 3.Imatinib for adjuvant therapy; 4.At least three imatinib concentrations can be obtained; 5.The available follow-up period should be at least 24 months;

Exclusion criteria

Exclusion criteria: 1.Imatinib for either neoadjuvant or palliative therapy; 2.Concomitant drugs that significantly affect the pharmacokinetics of IM (such as ketoconazole, itraconazole, erythromycin, clarithromycin, rifampicin, phenobarbital, phenytoin sodium, carbamazepine and oxcarbazepine); 3.Lack of relevant information for this study;

Design outcomes

Primary

MeasureTime frame
Recurrence rate;

Secondary

MeasureTime frame
Disease-Free Survival;

Countries

China

Contacts

Public ContactZhou Hong

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

whxh_zhou@hust.edu.cn+86 27 8535 1703

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026