Parkinson's disease
Conditions
Interventions
Nature Observation Group:None
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 40 years; 2.Meet the diagnostic criteria for primary Parkinson's disease (MDS Parkinson's Disease Diagnostic Criteria (2015 Edition)); 3.No medication adjustment in the 4 weeks before and during each stimulation; 4.MDS-UPDRS III score >= 8 points, Hoehn-Yahr score 1-4 points; 5.Mini-Mental State Examination (MMSE) score >= 22 points, and be able to complete behavioral tests and transcranial magnetic stimulation treatment.
Exclusion criteria
Exclusion criteria: 1.Focal brain injury or severe leukoencephalopathy (Fazekas grade 3 or above) on previous head MRI/CT scans; 2.Various secondary Parkinson's syndromes (vascular Parkinson's syndrome, drug-induced Parkinson's syndrome, etc.); 3.Severe craniocerebral trauma, cranial surgery or deep brain stimulation treatment; 4.Ferromagnetic implants in the body, such as cochlear implants, cardiac pacemakers, etc.; 5.A history of epilepsy, unexplained loss of consciousness, or taking anticonvulsant drugs for epileptic seizures; 6.Diagnosed with neuropsychiatric diseases other than Parkinson's disease; 7.A history of drug abuse or drug use; 8.Participated in any clinical trial in the past 6 months; 9.Pregnant/lactating women or subjects (including men) who plan to have children within 6 months; 10.Other situations that the researchers consider unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Multimodal fMRI related indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| MDS-UPDRS III improvement value;Biological tissue markers; | — |
Countries
China
Contacts
Public ContactPanpan Hu
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed