Borderline hypertension
Conditions
Interventions
Experiment One: Modeling Section:None
Experiment One: Verification Section:None
Experiment Two: Experimental Group:Nitrate intake of 0.15 mmol/kg per day
Experiment Two: Control Group:Standardized intervention
Sponsors
Beijing Stomatological Hospital , Capital Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Experiment One 1.Healthy individuals who deny a history of previous diseases; 2. Age: 20 to 65 years old, BMI: 20 to 25 kg/m^2, gender not limited; 3. Resting blood pressure values: SBP <140 mmHg and DBP < 90mmHg; 4. No history of taking drugs for treating hypertension; 5. The subjects can follow the plan for follow-up. Experiment Two 1.Healthy individuals who deny a history of previous diseases; 2. Age: 20 to 65 years old, BMI: 20 to 25 kg/m^2, gender not limited; 3. Resting blood pressure value SBP: 130-139 mmHg with DBP<=89 or DBP: 85-89 mmHg with SBP<=139; 4. No history of taking drugs for treating hypertension; 5. The subjects can follow the plan for follow-up.
Exclusion criteria
Exclusion criteria: Experiment One 1. Long-term consumption of foods rich in nitrates or nitrites; 2. Long-term use of antibacterial mouthwash; 3. Pregnant or lactating women; 4. Long-term smoking or drinking; 5. Currently participating in other clinical trials; 6. People with mental or intellectual disabilities; Experiment Two 1.Pregnant or lactating women; 2. Long-term smoking or drinking; 3. The dietary habit mainly consists of a high-nitrate diet; 4. Long-term use of antibacterial mouthwash; 5. People with mental or intellectual disabilities; 6. Currently participating in other clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Experiment 1: Resting Blood Pressure Values;Experiment 1: Serum Nitrate Level;Experiment 2: Resting Blood Pressure Values; | — |
Secondary
| Measure | Time frame |
|---|---|
| Experiment 1: Blood Oxygen Saturation;Experiment 1: Salivary Flow Rate;Experiment 2: 24-Hour Ambulatory Blood Pressure;Experiment 2: Salivary Nitrate Concentration;Experiment 2: Blood Oxygen Saturation;Experiment 2: Oral Nitrate-Reducing Capacity;Experiment 2: Salivary Flow Rate;Experiment 1: Oral Nitrate-Reducing Capacity;Experiment 1: Salivary Nitrate Level; | — |
Countries
China
Contacts
Public ContactQin Lizheng
Beijing Stomatological Hospital, Capital Medical University
Outcome results
None listed