Esophagus cancer
Conditions
Interventions
Gold Standard:Results from the endoscopic examination and histopathological testing
Index test:A panel of esophageal cancer-specific biomarkers comprising salivary miRNAs and oral microorganisms.
Sponsors
Changhai Hospital, Shanghai
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Subjects must meet all of the following criteria:(1) Aged >= 18 years; (2) Have undergone or are scheduled to undergo esophageal endoscopy, with available results from the endoscopic examination or histopathological testing; (3)Willing to participate in the study and capable of providing written informed consent.
Exclusion criteria
Exclusion criteria: Participants will be excluded if they meet any of the following criteria: (1) Women who are currently lactating or pregnant; (2) History of esophageal cancer; (3) Previous receipt of any therapeutic intervention for esophageal cancer (e.g., surgery, radiotherapy, chemotherapy, targeted therapy, or immunotherapy); (4) Diagnosis of any other primary malignancy within the past 5 years (except for individuals with a history of other cancers who have completed treatment and remained disease-free for over 5 years, who may be enrolled); (5) Severe impairment of cardiac, pulmonary, hepatic, or renal function, or any other severe systemic disease; (6) Active infectious diseases such as Hepatitis B, Hepatitis C, or HIV infection; (7) Presence of psychiatric or psychological disorders that would compromise the ability to comply with study requirements; (8) Inability to meet the sample collection requirements for the study's detection assays; (9) Any other condition deemed by the investigator to make the participant unsuitable for the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Accuracy; | — |
Countries
China
Contacts
Public ContactWang Luowei
Changhai Hospital
Outcome results
None listed