Study on the correlation between serum GDF-15 expression level and poor postoperative prognosis in elderly patients with preoperative frailty and hip fractures

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500110325

Enrollment

Unknown

Registered

2025-10-13

Start date

2025-10-13

Completion date

Unknown

Last updated

2025-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Geriatric hip fracture

Interventions

Frailty :No intervention measures

Non-frailty:No intervention measures

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients aged >=65 years, regardless of gender; 2. Surgical procedures: total or partial hip arthroplasty, intramedullary nailing of the femur, or plate-and-screw fixation of the femur; 3. Ability to communicate effectively verbally; if unable to communicate, a family member who is highly familiar with the patient’s condition may respond on their behalf and complete the frailty assessment.

Exclusion criteria

Exclusion criteria: 1. Patients undergoing emergency surgery; 2. Polytrauma patients with significant organ damage; 3. Pathological fractures; 4. Patients with severe neurological or psychiatric disorders who have family members unable to cooperate; 5. Patients who received glucocorticoids within one week prior to hospital admission up to the time of postoperative sample collection; 6. Patients with acute infection at the time of admission.

Design outcomes

Primary

Measure	Time frame
Intraoperative observation indicators (including anesthetic method, surgical procedure, duration of surgery, duration of anesthesia, intraoperative blood loss, intraoperative fluid administration, intraoperative blood transfusion, and whether vasopressors were used to maintain hemodynamic stability);Postoperative observation indicators (including postoperative PCA use, activities of daily living score, hospital length of stay, ICU stay duration, VAS pain score, and incidence of postoperative adverse events [e.g., wound infection, fracture, prosthesis loosening or dislocation, nerve injury, gastrointestinal dysfunction, cognitive impairment, respiratory dysfunction, thromboembolic events, and sleep disturbances]);Readmission and outcomes within 30 days postoperatively (cured/improved/deceased);Inflammatory markers (including IL-6, CRP, IL-10, GDF-15, etc.);	—

Measure

Time frame

Intraoperative observation indicators (including anesthetic method, surgical procedure, duration of surgery, duration of anesthesia, intraoperative blood loss, intraoperative fluid administration, intraoperative blood transfusion, and whether vasopressors were used to maintain hemodynamic stability);Postoperative observation indicators (including postoperative PCA use, activities of daily living score, hospital length of stay, ICU stay duration, VAS pain score, and incidence of postoperative adverse events [e.g., wound infection, fracture, prosthesis loosening or dislocation, nerve injury, gastrointestinal dysfunction, cognitive impairment, respiratory dysfunction, thromboembolic events, and sleep disturbances]);Readmission and outcomes within 30 days postoperatively (cured/improved/deceased);Inflammatory markers (including IL-6, CRP, IL-10, GDF-15, etc.);

—

Countries

China

Contacts

Public ContactLiu Xiaojing

Hunan Xiangtan Central Hospital

lxjcamellia@163.com+86 166 7340 8090

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026