Epilepsy
Conditions
Interventions
The brain tissue of hippocampus CA1 :None
The brain tissue of hippocampus CA2:None
The brain tissue of hippocampus CA3:None
The brain tissue of hippocampus CA4:None
The brain tissue of hippocampus DG:None
The brain tissue of hippocampus SUB:None
Sponsors
Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1)Meet the definition criteria defined by the 2010 International League Against Epilepsy (ILAE): Drug resistant epilepsy. 2)The epileptogenic zone was identified as temporal lobe epilepsy through neuroimaging, EEG monitoring, or functional imaging. 3) Postoperative pathological analysis reveals hippocampal sclerosis. 4)Obtain the approval from the hospital ethics committee, and with the informed consent of patients before inclusion.
Exclusion criteria
Exclusion criteria: 1)The epileptogenic zone does not meet the criteria of temporal lobe epilepsy through neuroimaging, EEG monitoring, or functional imaging. 2)Postoperative pathological analysis reveals drug-resistant epilepsy caused by other etiologies such as tumors and cortical dysplasia. 3) The hippocampal formation of the brain sample is incomplete.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proteins of the fresh frozen hippocampal tissue ; | — |
Countries
China
Contacts
Public ContactMei Liu
Affiliated Hospital of Zunyi Medical University
Outcome results
None listed