High-risk middle and lower Ureteral Urothelial Carcinoma
Conditions
Interventions
Radical nephreterectomy group:None
Sponsors
The Second Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18 to 80 years old; 2.Unilateral primary middle or lower ureteral urothelial carcinoma (confirmed by imaging and ureteroscopic biopsy); 3. Meets the EAU 2023 high-risk definition; 4. Voluntarily accept KSS or RNU, and have the technical feasibility confirmed by MDT discussion; 5.Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Multiple foci or involvement of the renal pelvis and upper ureter; 2.Bilateral UTUC; 3.cN+ or M1; 4.Previous ipsilateral upper urinary tract surgery; 5. Combined with other malignant tumors; 6.Pregnancy or breastfeeding; 7.No follow-up is possible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A five-year overall survival;Five-year cancer-specific survival ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Five-year recurrence-free survival;Five-year survival period without intravesical recurrence;Five-year metastasis-free survival;Incidence of a >=25% decline in eGFR and the rate of dialysis initiation.; | — |
Countries
China
Contacts
Public ContactShang Panfeng
Department of Urology, the Second Hospital of Lanzhou University
Outcome results
None listed