Schizophrenia with treatment-resistant auditory hallucinations
Conditions
Interventions
Active a-cTBS group:The patient received real stimulation intervention. The patient received cTBS stimulation in the targeted brain region (the temporoparietal junction). The stimulus is issued in a c
Sham a-cTBS group:The patient received pseudo-stimulus intervention. During the treatment, the Magstim pseudo-stimulation coil is placed at the same position as the true stimulation coil. Its shape is
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for schizophrenia as stipulated in the Diagnostic and Statistical Manual of Mental Disorders (5th Edition); 2. Age: 18 to 50 years old; 3. The auditory hallucinations of the participants remain unresponsive to at least two typical antipsychotic drugs after at least 6 weeks of adequate treatment. 4. All patients had been continuously using antipsychotic drugs for at least 3 months during the study period, and the dosage remained unchanged throughout the study period. 5. Right-handed; 6. No comorbid mental or neurological disorders;
Exclusion criteria
Exclusion criteria: 1.Participants with severe physical illnesses, infectious diseases, or immune system disorders. 2.Participants with severe neurological disorders, intellectual disability, or organic brain diseases; 3.Pregnant or breastfeeding women; 4.Participants who have received electroconvulsive therapy within the past 3 months; 5.A history of epileptic seizures. 6.Participation in previous or ongoing research projects, such as transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), or other neuromodulation interventions. 7.Implantation of metallic pacemakers, cardiovascular stents, intracranial electrodes, or similar devices. 8.Participants with claustrophobia or other fears related to magnetic resonance imaging (MRI) scanning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hoffman Auditory Hallucination Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Scores of the Adverse Event Record Form;Neurophysiological indices derived from electrophysiology;Scores on other clinical symptom and cognitive function-related scales; | — |
Countries
China
Contacts
Public ContactFu Jiayi
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed