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The study on the mechanism by which NETs mediate m6A modification of S100A9/TLR4/METTL3 activation exacerbates ferroptosis in sepsis-associated acute kidney injury

The study on the mechanism by which NETs mediate m6A modification of S100A9/TLR4/METTL3 activation exacerbates ferroptosis in sepsis-associated acute kidney injury

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500110307
Enrollment
Unknown
Registered
2025-10-11
Start date
2025-11-01
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis associated acute kidney injury

Interventions

Control group:None
SA-AKI:None

Sponsors

The first affiliated hospital of anhui medical university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Voluntarily sign the informed consent form and comply with the requirements of the protocol. 2.Age between 18 and 75 years old (including 18 and 75 years old), gender unspecified. 3.Sepsis patients;

Exclusion criteria

Exclusion criteria: 1.Pregnant or lactating women; 2.Patients with a history of severe renal insufficiency (patients receiving renal replacement therapy); 3.The researchers believe other circumstances that are not suitable for participating in this clinical trial;

Design outcomes

Primary

MeasureTime frame
ICU hospitalization duration;Mortality rate;—

Secondary

MeasureTime frame
Mechanical ventilation time;—

Countries

China

Contacts

Public ContactGong qian

The first affiliated hospital of anhui medical university

54xiaoqian@sina.com+86 182 2661 6000

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026