Gouty ankle arthritis
Conditions
Interventions
Experimental Group:Uric acid-lowering treatment and cycling
Control group:Uric acid-lowering treatment and jogging exercises
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.It meets the diagnostic criteria for gout of the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) in 2015; 2.There have been two histories of gout attacks on either side of the ankle joint in the past six months; 3.Ultrasound examination within the past 6 months indicated that either ankle joint had characteristic ultrasound manifestations (double-track sign, and/or hyperechoic aggregates, and/or tophi, and/or bone destruction). 4.Age: 18 to 60 years old, gender not limited; 5.Those who have had an interval of at least 4 weeks since the most recent acute gout attack; 6.If the patient is undergoing uric acid-lowering drug treatment, the drug dosage must remain stable for more than 4 weeks. During the study period, the uric acid-lowering drug regimen or dosage will not be adjusted; 7.For women who have the potential to become pregnant, a pregnancy test must be negative, they must not be in the lactation period, and it must be confirmed that they are receiving contraception approved by the researcher and agree to maintain this contraceptive measure throughout the study process; 8.Those who were informed of this study and signed the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Those who have received intra-articular injections of corticosteroids during an attack within the past three months; Those who have taken colchicine, NSAIDs, glucocorticoids in the past two weeks, or those who need to maintain anti-inflammatory drug treatment for a long time during the follow-up period; 2.Joint trauma or other types of arthritis; 3.There is a history of joint prosthesis or joint surgery; 4.Those who have had acute gout attacks within 4 weeks; 5.Patients with secondary gout caused by kidney diseases, blood disorders, or taking certain medications, radiotherapy and chemotherapy for tumors, etc; 6.Those with severe and unstable cardiovascular and cerebrovascular diseases (such as unstable angina pectoris, coronary angiogenesis, cerebral angiogenesis, transient ischemic attack, congestive heart failure, etc.) and other diseases that researchers have determined to be acute and difficult to control; 7.Those with active liver disease or abnormal liver function (ALT or AST=3 times the upper limit of the normal value); 8.Patients with abnormal renal function (eGFR=60ml/min/1.73m^2); 9.Those who have a history of alcohol abuse or are dependent on known drugs within the last two years; 10.Patients who were unable to complete the 6-month follow-up;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency of gout attacks; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events;Blood pressure;Blood uric acid;Gouty arthritis joint pain score;Ankle joint magnetic resonance;Ankle joint ultrasound;Heart rate; | — |
Countries
China
Contacts
Public ContactZhu Xiaoxia;Hua Yinghui
Huashan Hospital, Fudan University
Outcome results
None listed