Post-ablation thyroiditis
Conditions
Interventions
Selenium treatment group:Three days before the ablation procedure, oral administration of nano selenium capsules (2 capsules, 200 µ g/day) was started and continued until the end of the treatment cour
Placebo control group:Oral placebo capsules
Sponsors
China-Japan Union Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Undergo ultrasound-guided thermal ablation treatment. (2) Preoperative thyroid function (TSH, FT3, FT4) is basically normal. (3) Preoperative thyroid autoantibodies (TPOAb, TgAb) are negative or of low titer (clearly excluding active autoimmune thyroiditis as the main cause). (4) Preoperative thyroid echogenicity is disordered. (5) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Known to be allergic to selenium. (2) Severe dysfunction of heart, liver and kidney. (3) Active infection, malignant tumor, autoimmune disease (except stable Hashimoto's disease with negative/low titer anti-thyroid antibodies). (4) Pregnant or lactating women. (5) Recently (within < 3 months) used selenium supplements, glucocorticoids, immunosuppressants or drugs that may affect thyroid function. (6) History of previous thyroid surgery or ablation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thyroid lesion size;Thyroid function before microwave ablation;Thyroid function after microwave ablation;Preoperative blood selenium level before microwave ablation surgery;Preoperative blood selenium level after microwave ablation surgery;Thyroid echo;VAS Pain Rating Scale;Blood selenium enzyme level; | — |
Countries
China
Contacts
Public ContactTeng Dengke
China-Japan Union Hospital of Jilin University
Outcome results
None listed