Knee Osteoarthritis (KOA)
Conditions
Interventions
Sufentanil Group (Group SF):All anesthetic drugs were discontinued during the surgical skin closure. In Group SF, 10 µg of sufentanil was administered intravenously. After the operation, all patients
Oliceridine Group (Group OL):All anesthetic drugs were discontinued during the surgical skin closure. In Group OL, 2 mg of oliceridine was administered intravenously. After the operation, all patients
Sponsors
The Sixth People's Hospital of Shanghai
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective unilateral total knee arthroplasty 2.Aged 65-80 years, regardless of gender 3.American Society of Anesthesiologists (ASA) Physical Status Classification I-III
Exclusion criteria
Exclusion criteria: 1. History of total knee arthroplasty 2. History of severe cardiopulmonary underlying diseases 3. Severe liver and kidney dysfunction 4. History of allergy to anesthetics and local anesthetics 5. History of severe mental illness 6. Coagulation dysfunction 7. Long-term use of analgesic drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of Recovery-15 (QoR-15) Score;Extubation Time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Pressure (BP);Heart Rate (HR);Pulse Oxygen Saturation (SpO2);Awakening Time;Inflammatory Cytokines; | — |
Countries
China
Contacts
Public ContactZhangYing
The Sixth People's Hospital of Shanghai
Outcome results
None listed