Sepsis
Conditions
Interventions
Sepsis + Yousif treatment group:Patients were treated with conventional therapy plus oral yousipher (13-15 mg/kg/ day, divided into 2-3 doses according to the manufacturer's instructions) for 7 days.
Sepsis routine treatment group:All patients received routine anti-infection, fluid resuscitation, and organ support therapy according to the guidelines
Healthy control group:Without drug intervention, serum and stool samples were collected only once
Sponsors
Shanghai Fifth People's Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients (18-75 years old) who met the diagnostic criteria of Sepsis-3; 2. Sepsis or septic shock diagnosed within 24 hours before enrollment; 3. High risk of intestinal barrier dysfunction (such as SOFA score >=2 or risk factors for intestinal ischemia); 4. Informed consent was obtained from patients or their families.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. End-stage liver disease, unresolved biliary obstruction, or known allergy to bile acid drugs; 3.Expected survival time < 48 hours or withdrawal of active treatment; 4. Recent (< 7 days) use of other gut protective drugs (e.g., glutamine, probiotics).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal fecal a1-antiprotease levels (a marker of intestinal barrier permeability);Serum TUDCA and UDCA concentrations and their correlation with inflammatory factors; | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA score;APACHE II score;28-day mortality;Length of stay;Infection Control status;Serum inflammatory factors (IL-1ß, IL-6, TNF-a, IL-10); | — |
Countries
China
Contacts
Public ContactSun Keyuan
Shanghai Fifth People's Hospital Affiliated to Fudan University
Outcome results
None listed