Obesity
Conditions
Interventions
Cold exposure intervention group:Expose to a cold air environment with a temperature setting of 18 ° C for 2 hours
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
25 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Normal healthy volunteers aged 25 to 50, with normal weight (BMI: 19 to 24 kg/m^2); 2. Unconscious disorder, cognitive disorder, and normal communication skills; 3. Sign informed consent form.
Exclusion criteria
Exclusion criteria: 1.Have a history of smoking, cancer and long-term drug use; 2.Raynaud phenomenon; 3.People with claustrophobia; 4.Pregnant, pregnant or lactating women; 5.There is contrast agent allergy; 6.Implantable medical electronic instruments such as pacemakers; 7.There are medical electronic instruments such as artificial heart to maintain life or wearable medical electronic instruments such as electrocardiograph.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brown adipose tissue activity;Serum indicators related to adipose tissue: scEMC10, leptin, adiponectin, retinol binding protein 4 (RBP-4), fatty acid binding protein 4 (FABP-4), thyroid hormones (TSH, TT3, TT4, fT3, fT4), norepinephrine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory markers: interleukin-6 (IL-6), tumor necrosis factor alpha (TNF - a), C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP-1);Metabolic indicators: Blood lipids (total cholesterol, triglycerides, free fatty acids), fasting blood glucose, and insulin; | — |
Countries
China
Contacts
Public ContactQing Miao
Huashan Hospital, Fudan University
Outcome results
None listed