Hip fracture refers to a fracture of the femoral neck, femoral trochanter, or upper one-third of the femoral shaft (more than 5cm below the lesser trochanter)
Conditions
Interventions
Control group:5ml bupivacaine injection (25mg) + 25ml normal saline (total 30ml)
Experimental Group:20ml of liposomal bupivacaine (266mg) +5ml of bupivacaine injection (50mg) +5ml of normal saline (total 30ml)
Sponsors
Wuxi people’s Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Hip fracture patients undergoing surgical treatment under general anesthesia (including femoral neck fractures, intertrochanteric fractures; 2.The patient's ASA grade is ?-?; 3.Voluntary signing of informed consent form;
Exclusion criteria
Exclusion criteria: 1.Complex trauma: Patients with multiple fractures, including trauma to non-hip sites (e.g., head, chest, pelvis, and extremities); 2.History of mental illness or current use of psychotropic medications; 3.Preoperative delirium or consideration of using delirium treatment medications (e.g., olanzapine, haloperidol); 4.History of acute cerebrovascular disease (intracerebral or subarachnoid hemorrhage within 6 months); 5.Patients with impaired communication or language disorders; 6.Patients requiring sedation due to their condition or expected to be comatose postoperatively; 7.Allergy to amide-type local anesthetics; 8.Polycystic ovary syndrome or Wolff-Parkinson-White syndrome; 9.Second-degree or third-degree atrioventricular block/sinoatrial node syndrome without a pacemaker; 10.Admission electrocardiogram showing a ventricular rate <50 beats/min or Q-T interval prolongation; 11.Severe hepatic or renal insufficiency; 12.Participation in other clinical studies; 13.History of drug addiction or abuse; 14.Significant coagulation dysfunction or requirement for blood transfusion;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep quality;Mental status; | — |
Secondary
| Measure | Time frame |
|---|---|
| Related inflammatory factors (IL - 1ß, IL - 6, TNF - a);Postoperative adverse reactions (dizziness, nausea and vomiting, hypotension, respiratory depression, bradycardia) and their frequencies;Length of hospital stay;Pain scores at rest and during movement and area under the curve (AUC);Dosages of sufentanil and flurbiprofen axetil after surgery; | — |
Countries
China
Contacts
Public ContactLu Shunmei
Wuxi People's Hospital
Outcome results
None listed