Ocular diseases
Conditions
Interventions
Group 1: Diagnosed with ocular diseases but have not received any intervention :N/A
Group 2: Diagnosed with ocular diseases and are receiving treatments:N/A
Group 3: sex- and age-matched healthy controls :N/A
Sponsors
Department of Ophthalmology and Visual Sciences (DOVS), Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
6 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 6-80 years. 2. Group 1: Diagnosed with ocular diseases but have not received any intervention; Group 2: Diagnosed with ocular diseases and are receiving treatments; Group 3: Apparently healthy with no history of eye trauma/surgery. 3. Agree to join the study by signing written assent and/or informed consent.
Exclusion criteria
Exclusion criteria: 1. Refuse to have blood/tears/aqueous humor/vitreous humor taken; 2. Non-detectable EVs in the sample; 3. For Group 3: History of systematic diseases or any abnormal findings in ophthalmological examinations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression profile of EV-derived miRNA of the biofluid from patients with ocular disease and sex- and age-matched healthy controls in Hong Kong; | — |
Secondary
| Measure | Time frame |
|---|---|
| Alterations in EV-derived miRNA compositions across different ocular diseases;Associations between specific EV-derived miRNA profiles and disease progression/severity;Correlation between EV-derived miRNA patterns and treatment responses/outcomes;Relationships between EV-derived miRNA expression and traditional clinical biomarkers (P<0.05);Comparison of EV-derived miRNA patterns between different body fluid sources;Technical optimization for EV-derived miRNA isolation and detection from limited ocular samples; | — |
Countries
China
Contacts
Public ContactJason Cheuk Sing YAM
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong
Outcome results
None listed