overweight
Conditions
Interventions
High-quality Low-Carbohydrate Diet group (hLCD):Meals are consumed within three conventional meal times, with the last meal finished by 19:00. Macronutrient distribution: 27% carbohydrates, 30% protei
8-hour Time-Restricted Eating group (8-h TRE):>=85% of total daily energy intake is consumed between 07:30 and 15:30
the remaining energy must be consumed between 15:30 and 17:00 on the same day. Macronutrient distribution: 55% carbohydrates, 20% protein, 25% fat.
During the intervention, they would be required to c
High-quality LCD + 8-hour Time-Restricted Eating group (hLCD+8-h TRE):>=85% of total daily energy intake is consumed between 07:30 and 15:30
the remaining energy must be consumed between 15:30 and 17:00 on the same day. Macronutrient distribution: 27% carbohydrates, 30% protein, 43% fat.
During the intervention, they would be required to c
Control group:Meals are consumed within three conventional meal times, with the last meal finished by 19:00. Macronutrient distribution: 55% carbohydrates, 20% protein, 25% fat. They would receive a g
Sponsors
Guangzhou overseas Chinese hospital, The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Chinese Han nationality, aged 18-50 years 2. BMI 25-35 kg/m^2, or meeting one of the following criteria (1) waist circumference >=90cm(male)or >=85cm(female) (2) waist to hip ratio >=0.5 (3) Body fat >=25%(male)or >=30%(female) (4) Visceral fat area >=80cm^2 3. In the past week, individuals with low-intensity physical activity (METs 1.5–2.9; heart rate <64% of maximum heart rate, where *maximum heart rate = 207 – 0.7 × age [years]*) or daily steps <10,000 were categorized as having low activity levels
Exclusion criteria
Exclusion criteria: 1. Pregnant women, women preparing for pregnancy, and lactating women; 2. Moderate/high-intensity physical activity in the past week or daily step count > 10,000; 3. History of heart, liver, kidney, brain, hematopoietic, immune, or thyroid diseases; malignant tumors; gastrointestinal diseases (e.g., malabsorption or indigestion); or anorexia nervosa; 4. Weight change exceeding 5% in the past three months; irregular eating patterns in the past three months (inconsistent mealtimes); dieting and/or significant lifestyle changes (e.g., daily fasting for 15 hours in the past three months or more than 12 instances of 24-hour fasting in the past year); 5. Use of medications or supplements known to affect body fat, muscle mass, or blood glucose in the past two weeks (e.g., insulin, liraglutide, semaglutide, tirzepatide [GIP/GLP-1 receptor dual agonist], mazdutide, statins, beta-blockers, etc.); 6. Having undergone weight loss surgery in the past three months or planning to undergo such surgery in the next three months; 7. Cognitive or mental impairments that prevent completion of questionnaires; physical disabilities that impair normal walking; 8. Failure to provide informed consent, or other reasons deemed by the investigator as unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight;Body composition;Hip circumference;Waist circumference;Visceral Fat Content; | — |
Secondary
| Measure | Time frame |
|---|---|
| GLP-1;INS;Resistin;ALB;Human Peptide YY;AST;Ghrelin;ALT;IL-6;blood lipid profiles;Blood glucose;Leptin;UREA;CRP;ADP;Creatinine;TP;Non-targeted metabolome;Gut microbiota; | — |
Countries
China
Contacts
Public ContactYanbin Ye
Guangzhou overseas Chinese hospital, The First Affiliated Hospital of Jinan University
Outcome results
None listed