Decline in kidney function / renal insufficiency Reduced urine output Edema (leg or generalized swelling) Worsening hypertension Fatigue and weakness Electrolyte imbalance (e.g., hyperkalemia)
Conditions
Interventions
Kidney tumor patient group:None
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients with pathologically confirmed or radiologically highly suspected renal cell carcinoma (RCC), meeting the clinical diagnostic criteria for locally advanced or high-risk RCC, and planned for surgical resection; 2.Scheduled to undergo radical or partial nephrectomy, with postoperative adjuvant therapy (e.g., targeted therapy, immunotherapy) considered as appropriate; 3.Availability of complete preoperative clinical evaluation data, including imaging examinations (contrast-enhanced CT, MRI, renal dynamic scintigraphy, etc.) and laboratory indicators (e.g., renal function, tumor biomarkers); 4.Age >=18 years, no gender restriction; 5.No concurrent active malignancy and no severe comorbidities that would compromise the safety of surgery or adjuvant treatment; 6.Multidisciplinary team (MDT) evaluation confirming eligibility for surgery and individualized adjuvant therapy.
Exclusion criteria
Exclusion criteria: 1.Non-RCC cases or unclear pathological diagnosis; 2.Prior systemic targeted therapy, immunotherapy, or radiotherapy, with current recurrence or advanced metastatic disease; 3.Severe cardiopulmonary insufficiency, hepatic/renal failure, active infection, or other conditions precluding tolerance to surgery or adjuvant therapy; 4.Severe psychiatric disorders, cognitive impairment, or other conditions affecting study compliance; 5.Inability to comply with postoperative follow-up or anticipated inability to complete required assessments and data collection during the study period; 6.Participation in other interventional clinical trials that may interfere with study outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative renal function;Progression-Free Survival;Overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative complication incidence;Hospitalization duration;Postoperative recovery quality; | — |
Countries
China
Contacts
Public ContactQi Zhang
Zhejiang Provincial People's Hospital
Outcome results
None listed