hereditary thrombophilia
Conditions
Interventions
observation group:N/A
Sponsors
Fujian Maternity and Child Health Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Patients are < 18 years old at the time of VTE, and their guardians or adult family members voluntarily participate in the study and sign the informed consent form. 2. Nuclear family member (at least one child and one parent diagnosed with VTE) or non-nuclear family member (probanded person and their sibling diagnosed with VTE). 3. Antithrombin (AT) deficiency (<30%) and/or protein C deficiency (<30%) and/or protein S deficiency (<30%).
Exclusion criteria
Exclusion criteria: 1. Autoimmune diseases: antiphospholipid syndrome, vasculitis, systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, idiopathic inflammatory myopathy, systemic sclerosis, chronic kidney disease, inflammatory bowel disease, etc. 2. Severe infection: Sequential Organ Failure Assessment (SOFA) score increases by >=2 points from the baseline level, such as diagnosis of purulent meningitis, bronchopneumonia, infective endocarditis, septic shock, etc. 3. Malignant tumors. 4. Blood diseases: autoimmune hemolytic anemia AIHA, paroxysmal nocturnal hemoglobinouria PNH, heparin-induced thrombocytopenia HIT, etc. 5. Difficult surgery with high risk of level 3 or 4, involving important organs (such as heart, liver, craniocerebrum, large blood vessels); organ transplantation, etc. 6. Recent blood transfusion history (< 3 months).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thrombophilia susceptibility genes;Venous thromboembolism; | — |
Countries
China
Contacts
Public ContactJinhua Zhang
Fujian Maternity and Child Health Hospital
Outcome results
None listed