Effects of different doses of esketamine pretreatment on postoperative sore throat after double-lumen endobronchial intubation:A randomized double-blind controlled study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500110242

Enrollment

Unknown

Registered

2025-10-11

Start date

2024-03-08

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Test group 1:esketamine 0.05mg/kg

Test group 2:esketamine 0.075mg/kg

Test group 3:esketamine 0.1mg/kg

control group:Normal saline 2ml

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age 18 to 65 years old ; 2. Women and men are not limited ; 3. Body Mass Index 20 ~ 30kg / m^2 ; 4. American Society of Anesthesiologists ( ASA ) grade I ~ II ; 5.Patients undergoing elective thoracoscopic lung surgery.

Exclusion criteria

Exclusion criteria: 1. Patients allergic to anesthetics ; 2. Patients with chronic cough, pharyngitis, sore throat, asthma ; 3. Intubation or extubation is not smooth ; 4. Perioperative need through the mouth or through the nose into the stomach tube, nutrition tube ; 5. Severe hypertension, cerebrovascular disease, epilepsy, mental illness, severe organ dysfunction, lactating women, etc. ; 6. Unclear speech can not be evaluated normally.

Design outcomes

Primary

Measure	Time frame
the incidence and severity of sore throat;	—

Secondary

Measure	Time frame
heart rate;blood pressure;pulse oxygen saturation;dizziness;nausea and vomiting;mental symptom;recovery time;extubation time;bispectral index of EEG;	—

Countries

China

Contacts

Public ContactDong Xiaoli

Lishui People's Hospital

xuqiaomin810@163.com+86 189 5709 3880

Outcome results