Stroke
Conditions
Interventions
Trial group:The intensive nutritional treatment plan was initiated within 48 hours after the patients admission. On the basis of normal oral feeding, 500ml of pre-prepared nutritional solution (contai
Control group:The routine nutritional treatment plan should be initiated within 48 hours after the patient is admitted. The patients eating situation should be dynamically observed and nutritional hea
Sponsors
Stroke Center of the First Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Diagnosis of stroke confirmed by head CT or MRI; 3. NIHSS score <= 25; 4. PNI <= 44.15 (low PNI).
Exclusion criteria
Exclusion criteria: 1. Patients with inability to take oral intake due to any cause; 2. Patients with signs of infection within 1 week prior to admission, such as temperature >37.3 °C accompanied by chills or fatigue; cough with purulent sputum, etc.; 3. Patients with significantly abnormal gastrointestinal function, including frequent vomiting or diarrhea, or those with contraindications to enteral nutrition; 4. Patients with severe comorbid medical conditions; severe hepatic or renal dysfunction: severe hepatic dysfunction is defined as ALT >2 times the upper limit of normal (ULN) or AST >2 times the ULN; severe renal dysfunction is defined as serum creatinine >1.5 times the ULN and CrCl <30 mL/min; 5. Patients with tracheostomy; or any organic lesions of the airway or esophagus; 6. Patients who received enteral nutritional support prior to hospital admission; 7. Pregnant or lactating women; 8. Patients with an expected survival of less than 3 months, or those unable to complete the study for other reasons; 9. Patients with hypersensitivity to any component of the study formulation, or with congenital metabolic disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Independence Measure (FIM) Score;Prognostic Nutritional Index (PNI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical criterion;The difference in the change of the prognostic nutritional index compared to the baseline;Body Mass Index (BMI);Strength of the healthy upper limb;Body composition analysis;National Institutes of Health Stroke Scale (NIHSS);Activities of Daily Living (ADL) Assessment;Mini Nutritional Assessment;Modified Rankin Scale (mRS); | — |
Countries
China
Contacts
Public ContactYan Xiuli
The first hospital of Jilin University
Outcome results
None listed