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Comparison of the clinical effects of remimazolam tosylate and propofol in elderly patients undergoing laparoscopic cholecystectomy: Exploring optimized anesthesia strategies and improving postoperative recovery

Comparison of the clinical effects of remimazolam tosylate and propofol in elderly patients undergoing laparoscopic cholecystectomy: Exploring optimized anesthesia strategies and improving postoperative recovery

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500110234
Enrollment
Unknown
Registered
2025-10-10
Start date
2025-10-10
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

laparoscopic cholecystectomy

Interventions

R Group:The anesthetic induction was performed using remimazolam tosylate at a dose of 0.2-0.3 mg/kg, and the anesthesia was maintained at a rate of 1-3 mg/kg/h through continuous infusion.
P Group:Propofol was administered at a dose of 1.5-2.5 mg/kg for induction of anesthesia, and maintained at a rate of 3-9 mg/kg/h through continuous infusion.

Sponsors

The First Affiliated Hospital of Kunming Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: (1) Patients scheduled to undergo elective cholecystectomy via laparoscopy; (2) Age >= 18 years; (3) ASA classification: I-III; (4) Have sufficient cognitive ability to understand and participate in the research process.

Exclusion criteria

Exclusion criteria: (1) Recent respiratory tract infection; (2) Severe heart and lung diseases: including severe heart failure or severe lung failure; (3) Severe damage to liver or kidney functions (liver cirrhosis at Child-Pugh C grade or renal failure requiring dialysis) and liver and kidney transplant surgeries; (4) Pregnant or lactating women; (5) Patients with a history of addiction to sedative drugs, anesthetic drugs, alcohol, etc.; (6) Known allergic history to anesthetic drugs; (7) Emergency surgeries.

Design outcomes

Primary

MeasureTime frame
The area under the baseline (AUB)throughout the procedure;

Secondary

MeasureTime frame
Heart rate;

Countries

China

Contacts

Public ContactYu Fang

The First Affiliated Hospital of Kunming Medical University

fangyu@ydyy.cn+86 138 8809 1314

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026