Stroke
Conditions
Interventions
Treatment Group(patients):Transcutaneous auricular vagus nerve stimulation (taVNS) was administered synchronously during 30-minute conventional swallowing rehabilitation training in stroke patients.
Control Group(patients):The sham stimulation uses a subthreshold stimulation intensity.
Intervention Group(healthy individuals):Transcutaneous auricular vagus nerve stimulation (taVNS) was administered simultaneously with 30 minutes of swallowing-related exercises in healthy individuals.
Sponsors
Department of Rehabilitation Medicine, Sir Run Run Hospital, Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients:1.First onset of unilateral supratentorial cerebral infarction or cerebral hemorrhage, confirmed by CT or MRI;2. Aged between 18 and 80 years;3.Within one week to six months after onset;4. A Water Swallow Test score >= 3;5. Montreal Cognitive Assessment (MoCA) score > 18. Healthy individuals: 1. Aged 18 and above, all genders; 2.Without significant cognitive impairments or severe neurological disorders that may affect study outcomes.
Exclusion criteria
Exclusion criteria: 1. Implanted electronic devices (e.g., cardiac pacemakers); 2. Dysphagia caused by other neurological disorders such as Parkinson’s disease or multiple sclerosis; 3. History of vagotomy or vagus nerve injury; structural diseases of the esophagus or larynx; 4. Skin conditions that may interfere with stimulation or device placement, including scar tissue, skin lesions, or active diseases of the auricle and external auditory canal; 5. Severe cardiac, pulmonary, or hepatic dysfunction; 6. Resting heart rate < 60 beats per minute.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Task-related HbO2 concentration changes (changes in cerebral blood flow).;Heart rate variability;Motor-evoked potentials, MEP;A Water Swallow Test;Modified Mann Assessment of Swallowing(MASA);Standardized Swallowing Assessment(SSA);Swallowing Quality of life;surface electromyography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional Oral Intake Scale;Montreal Cognitive Assessment;Modified Barthel Index;Fatigue Severity Scale;swallowing sound; | — |
Countries
China
Contacts
Public ContactZhongli Jiang
Department of Rehabilitation Medicine, Sir Run Run Hospital, Nanjing Medical University
Outcome results
None listed