postoperative delirium
Conditions
Interventions
Nil Per Os(NPO) after Midnight group:Conventional preoperative fasting with nil per os (NPO) after midnight
preoperative oral carbohydrate group:Ingestion of 400ml of a carbohydrate-rich clear liquid beverage 2 to 3 hours before surgery
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged 60 years and above; 2.ASA class I-III; 3.Scheduled for elective non-cardiac surgery;
Exclusion criteria
Exclusion criteria: 1.Patients with conditions that increase the risk of aspiration (including gastroesophageal reflux disease, hiatal hernia, Zenker's diverticulum, pyloric stenosis, achalasia, gastroparesis, gastrointestinal obstruction, obesity, and those using medications that delay gastric emptying; 2.Patients with diabetes mellitus or impaired glucose tolerance; 3.Patients with a history of psychiatric disorders or conditions requiring long-term psychotropic medication (e.g., dementia, schizophrenia) or a history of alcoholism; 4.Patients with a history of cerebrovascular events within the past 3 months, such as stroke or transient ischemic attack (TIA); 5.Patients with abnormal liver or renal function: ALT or AST > 2 times the upper limit of normal, or CrCl < 30 mL/min; 6.Patients with an ejection fraction (EF) < 30% on echocardiography; second-degree type 2 or third-degree atrioventricular block; or a history of active cardiac disease (e.g., acute myocardial infarction, unstable angina); 7.Patients who have participated in another clinical trial within 4 weeks prior to enrollment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postoperative nausea and vomiting (PONV) within 24 hours and the utilization of antiemetic medications.;Plasma osmolality, hematocrit, and electrolyte levels (sodium, potassium, calcium, lactate) at 30 minutes before surgery.;The degree of thirst, hunger, nausea, headache, dizziness, and anxiety 30 minutes before surgery.;Time to first flatus and defecation, and length of postoperative hospital stay.;Parameters measured on the first postoperative day included inflammatory mediators (IL-6, CRP), fasting blood glucose, insulin levels, the postoperative insulin resistance index, and the incidence of;Duration, severity, and subtypes of postoperative delirium.;Quality of Recovery at 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactYan Luo
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed