None listed
Conditions
Interventions
Short-term oxygen inhalation intervention group:Nasal cannula oxygen supply, with a flow rate of 2 L/min, for a duration of 2 hours
Indoor gradient diffusion oxygen (oxygen concentration Range: 21%-26.3%)
Gradient pressurization in a hyperbaric oxygen chamber (pressure range: 79.7 kPa–89.9 kPa, oxygen concentration range: 21%–26.3%)
Long-term oxygen inhalation intervention group:8-hour indoor diffuse oxygen at night, oxygen concentration Range: 21%-26.3%
Sponsors
Peking University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Short-term oxygen inhalation intervention group: 1. Age ranging from 18 to 65 years old; 2. Healthy, without major chronic diseases (such as heart disease, chronic obstructive pulmonary disease, severe metabolic diseases, etc.); 3. Signed informed consent form and can cooperate with follow-up. Long-term oxygen inhalation intervention group: 1. Age ranging from 18 to 65 years old; 2. Healthy, without major chronic diseases (such as heart disease, chronic obstructive pulmonary disease, severe metabolic diseases, etc.); 3. Signed informed consent form and can cooperate with follow-up.
Exclusion criteria
Exclusion criteria: Short-term oxygen inhalation intervention group: 1. Received major surgery within the past six months; 2. Has a history of smoking or heavy drinking; 3. Has mental illness or is unable to cooperate with physical examination; 4. People who have lived in the plateau area for generations; 5. Has a regular oxygen inhalation habit (average daily oxygen inhalation duration is more than 1 hour). Long-term oxygen inhalation intervention group: 1. Received major surgery within the past six months; 2. Has a history of smoking or heavy drinking; 3. Has mental illness or is unable to cooperate with physical examination; 4. People who have lived in the plateau area for generations; 5. Has a regular oxygen inhalation habit (average daily oxygen inhalation duration is more than 1 hour).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Oxygen Saturation;lung function: Forced Expiratory Volume in 1 second;lung function: forced vital capacity;lung function: peak expiratory flow;Vital Capacity;pulse wave velocity;blood cell count;reactive hyperemia index;Resting-state Functional Magnetic Resonance Imaging (rs-fMRI);Oxygen Uptake;Maximal Oxygen Consumption;Anaerobic Threshold;Oxygen Consumption Rate;Systolic Blood Pressure;TNF-a;Norepinephrine;Cortisol;Cardiac Troponin;C-reactive Protein;D-Dimer;Interleukin-6;Pulmonary Artery Pressure;RVOT;Cognition Function;TV;Sleep Quality;Body Temperature;RHI;CRP;gray and white matter of brain;blood glucose;Insulin;glycosylated hemoglobin;Routine urinalysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| body mass index;Sleep Time;Fraction Exhaled Nitric Oxide (FeNO);Alpha Power;Standard Deviation of NN Intervals;Root Mean Square of Successive Differences;Low Frequency;High Frequency;Diastolic Blood Pressure;Pulse Pressure;Ejection Fraction;Stroke Volume;Cardiac Output;High-density Lipoprotein Cholesterol;Total Cholesterol;Triglycerides;Aspartate Aminotransferase;Coagulation Time;Plasminogen Activator Inhibitor-1;Von Willebrand Factor;Thromboxane B2;Thrombin-antithrombin Complex;Transcranial Doppler;DNA Adducts;Epigenome;Metabolomics;Proteomics;Transcriptomics;MDA;Cystatin C;Augmentation Index;Microbiome;intraocular pressure;eyeground blood flow;tear film; | — |
Countries
China
Contacts
Public ContactJicheng Gong
Peking University
Outcome results
None listed