Lung cancer
Conditions
Interventions
Group A:Fluoropyrofen ester 1 mg/kg (IV injection 15 minutes prior to anesthesia induction) + FiO2 60% (from initiation of single-lung ventilation until completion of surgery)
Group B:Flurbiprofen ester 1 mg/kg (IV injection 15 minutes prior to anesthesia induction) + FiO280% (from initiation of single-lung
Group C:Normal saline (IV infusion 15 minutes prior to induction of anesthesia) + FiO2 60% (from initiation of single-lung ventilation
Group D:Normal saline (IV infusion 15 minutes prior to induction of anesthesia) + FiO2 80% (from initiation of single-lung ventilation
Sponsors
The Fourth Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients undergoing elective unilateral thoracoscopic lobectomy with single-lung ventilation using a occluder (either left or right lobe), of any gender, aged 18–64 years, with a BMI of 18.5–27.9 kg/m^2, and ASA physical status classification of I–III. Preoperative pulmonary function: FEV1/FVC >= 70%.
Exclusion criteria
Exclusion criteria: 1. Exclusion Criteria: History of severe cardiovascular or respiratory disease prior to surgery; history of abuse of anesthetic analgesics; history of psychiatric or neurological disorders; patients with peptic ulcers; patients with severe hepatic, renal, or hematologic dysfunction; patients with severe heart failure or hypertension; patients with a history of allergy to dexmedetomidine, flurbiprofen esters, aspirin-induced asthma or history thereof, current use of levofloxacin, lomefloxacin, or norfloxacin, nonsteroidal anti-inflammatory drug (NSAID) use within 24 hours prior to surgery, contraindications to flurbiprofen ester use, lactation, or contraindications to occluder use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation Index (OI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Iactate level;Airway peak pressure, Ppeak;plateau airway pressure;Pulmonary dynamic compliance, Cdyn;Ratio of void cavity to tidal volume; | — |
Countries
China
Contacts
Public ContactHuanshuang Pei
The Fourth Hospital of Hebei Medical University
Outcome results
None listed