Gynecologic Laparoscopic Surgery
Conditions
Interventions
Group O:After intraoperative specimen removal, connect to an intravenous analgesic pump. Group O: Administer an intravenous loading dose of 0.04 mg/kg Oliceridine
Analgesic pump formulation: 0.35 mg/kg Oliceridine diluted with normal saline to 100 ml, infusion rate 2 ml/h, bolus dose 0.5 ml.
Group S:After intraoperative specimen removal, connect to an intravenous analgesic pump. Administer an intravenous loading dose of sufentanil 0.2 µg/kg. Analgesic pump formulation: 2 µg/kg sufentanil
Sponsors
Anqing Municipal Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for elective gynecologic laparoscopic surgery; 2.ASA physical status I-III; 3.Age 18-65 years; 4.BMI 18-32 kg/m^2, and body weight >40 kg; 5.Meets ethical standards, voluntarily participates in the trial, and provides signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Severe cardiac, pulmonary, hepatic, or renal dysfunction; 2.History of psychiatric disorders, long-term use of psychotropic drugs, chronic analgesic medication use, or history of alcoholism; 3.Patients with severe infections; 4.Language or hearing impairment, or cerebral dysfunction such as stroke, unable to communicate; 5.Preoperative PaO2 <60 mmHg or SpO2 <92%; 6.Participation in another drug clinical trial within the past 30 days; 7.Patient or family refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of moderate to severe acute pain (NRS score >3 or requiring rescue analgesia) within 24 hours postoperatively.;Time to first flatus postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative dynamic pain NRS scores: NRS scores at rest and during coughing immediately, 0.5 h, 2 h, 6 h, and 24 h after laryngeal mask airway removal;Mean postoperative dynamic pain NRS scores: Area under the curve/24h of NRS scores at rest and during coughing immediately, 0.5 h, 2 h, 6 h, and 24 h after laryngeal mask removal;Postoperative 24h PCIA attempts;Postoperative rescue analgesia: Time to first rescue analgesia, number of rescue analgesia events within 24h, total dosage of rescue analgesics;Incidence of chronic pain: Incidence of chronic pain at 1 month and 3 months postoperatively;Time to first defecation postoperatively: The time interval from the end of surgery to the first defecation;Time to first ambulation postoperatively: The time from the end of surgery to the first ambulation; Postoperative GI function score (I-FEED): 5 components (oral intake, nausea, vomiting, abdominal distension symptoms, and symptom duration); | — |
Countries
China
Contacts
Public ContactDuan Jinjuan
Anqing Municipal Hospital
Outcome results
None listed