Postoperative analgesia in patients undergoing bariatric surgery
Conditions
Interventions
Morphine group:The morphine loading dose was 5.0 mg before suturing, and 125mg of morphine was diluted to 100ml with 0.9% normal saline.
Sufentanil group:The load dose of sufentanil injection was 5.0ug before suturing, 125ug sufentanil +0.9% normal saline was diluted to 100ml.
Oliceridine group:Oliceridine fumarate injection was given at a loading dose of 1.0mg and 25mg oxelidine +0.9% normal saline diluted to 100ml before sutures.
Sponsors
Central Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign informed consent, fully understand the purpose and significance of this test, and voluntarily comply with this test procedure; 2. Laparoscopic weight loss surgery under general anesthesia should be performed at an appropriate time, and the operation duration should be >=1h; 3. 18 years old 27.5 kg/m² combined with obesity-related diseases, or simply BMI > 32.5 kg/m²; 5. ASA is graded as I to II.
Exclusion criteria
Exclusion criteria: 1. A history of vestibular dysfunction or dizziness, nausea, retching, and vomiting in the week before screening; 2. Previous psychiatric diseases (such as schizophrenia, depression, etc.) and cognitive dysfunction, or a history of epilepsy, Parkinson's syndrome; 3. Known prior allergy to opioids and other drugs that may be used during the trial, such as antiemetics; 4. Continuous use of opioid analgesics for any reason for more than 10 days in the 3 months prior to randomization, or the last time the drug was administered shorter than the 5-half-life of the drug; 5. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting within 24 h; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of subjects who did not use remedial analgesics after surgery;;Time of first use of remedial analgesics, number of remedial analgesics within 24 h, cumulative use of remedial analgesics;;The frequency and severity of nausea at 2 hours, 6 hours, 12 hours and 24 hours after surgery;The frequency and severity of vomiting at 2 hours, 6 hours, 12 hours and 24 hours post-operation;The number of postoperative antiemetic drug uses and cumulative dose;Ramsay sedation scores at 2 hours, 6 hours, 12 hours and 24 hours after the operation;The frequency and duration of respiratory depression within 24 hours;The number of PCA compressions within 24 hours;The time when the resting NRS was first reduced to = 3 and the time when the cough NRS was first reduced to = 3;Length of hospital stay and total cost;Patient and doctor satisfaction scores (on a scale of 0 to 10); | — |
Countries
China
Contacts
Public ContactFanjun Meng
Central Hospital Affiliated to Shandong First Medical University
Outcome results
None listed