Lung injury
Conditions
Interventions
HFNC group:Immediately after extubation, patients receive high-flow nasal cannula (HFNC) oxygen therapy using the AIRVO 2 device with a flow rate of 50–60 L/min, initial FiO% of 50% adjusted to mainta
Control Group:Immediately after extubation, patients receive conventional face mask oxygen therapy at a flow rate of 6–8 L/min for 2 hours.
Sponsors
The First Affiliated Hospital of Bengbu Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 72 Years
Inclusion criteria
Inclusion criteria: The study participants were obese (BMI = 25 kg/m²) patients scheduled to undergo thoracoscopic surgery with one-lung ventilation under general anesthesia, meeting the following criteria: 1. Aged 18–72 years 2. BMI = 25 kg/m² 3. ASA physical status classification of I–III 4. Scheduled for elective thoracoscopic surgery with one-lung ventilation, with an anticipated operative duration of 1–3 hours
Exclusion criteria
Exclusion criteria: Patients presenting with any of the following conditions were excluded from the study: 1. Refusal to sign informed consent; 2. History of acute respiratory infection within 2 weeks prior to surgery; 3. Communication barriers due to psychiatric disorders, language impairment, or visual/hearing impairments; 4. Scheduled operative duration 3 hours; 5. Comorbid severe COPD, asthma, or other restrictive ventilatory disorders; 6. Preoperative requirement for continuous oxygen therapy or dependence on non-invasive/invasive ventilator support; 7. Severe cardiac dysfunction (NYHA class IV), abnormal liver function (Child-Pugh grade C), severe renal dysfunction (requiring preoperative dialysis), or ASA physical status =IV; 8. Intraoperative conversion to open thoracotomy; 9. Other conditions deemed by the investigators or attending physician to render the patient unsuitable for study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oxygenation index (PaO%/FiO%); | — |
Secondary
| Measure | Time frame |
|---|---|
| sRAGE;Frequency and duration of hypoxemic events (SpO? <92%) within 72 h postoperatively.;Incidence of respiratory complications (pneumonia, reintubation, ARDS, respiratory failure, etc.).;ICU and total hospital length of stay; | — |
Countries
China
Contacts
Public ContactBiao Xi
The First Affiliated Hospital of Bengbu Medical University
Outcome results
None listed