Refractory Hypertension, Drug-Intolerant Hypertension
Conditions
Interventions
Intervention Group:Laparoscopic Renal Artery Radiofrequency Denervation combined with standardized antihypertensive medication
Sponsors
Fuwai Central China Cardiovascular Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age >=18 and =140 mmHg and =180 mmHg, and office diastolic blood pressure (DBP) >=90 mmHg; 5.Blood pressure remains uncontrolled after at least 28 days of standardized treatment with at least three antihypertensive drugs (including a diuretic) with >=80% compliance; 6.Patient has good compliance, is willing to complete clinical follow-ups, and has signed the informed consent form. 7.24-hour ambulatory SBP >=130 mmHg or daytime average SBP >=135 mmHg.
Exclusion criteria
Exclusion criteria: 1.Secondary hypertension; 2.Unsuitable renal artery anatomy (e.g., diameter >9mm or 50%); 3.Unsuitable for laparoscopic surgery via retroperitoneal approach (e.g., morbid obesity with BMI > 40 kg/m²); 4.Severe renal impairment (eGFR < 45mL/min/1.73m²); 5.Hospitalization for hypertensive crisis within the past year; 6.History of cardiovascular or cerebrovascular events (e.g., myocardial infarction, stroke) within the 6 months prior to screening; 7.Pregnant or planning to become pregnant; 8.Subjects deemed unsuitable for the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of achieving target office systolic blood pressure at 180 days; | — |
Countries
China
Contacts
Public ContactChuanyu Gao
Fuwai Central China Cardiovascular Hospital
Outcome results
None listed