Migraine
Conditions
Interventions
Individual localization therapy group:Individual orientation
Traditional localization therapy group:Traditional localization
Sponsors
The First Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.18-65 years old; Both men and women; 2.Patients diagnosed with migraine according to the International Classification of Headache Disorders (ICHD-III) , first onset before age 50, and a history of migraine >1 year; 3.>=4 days per month in the 3 months before the screening period and during the screening period; 4.Informed consent documents are signed, subjects cooperate to complete the assessment and rTMS treatment, and are informed of any known and potential risks and available alternative treatments.
Exclusion criteria
Exclusion criteria: 1.Patients with TMS contraindications (metal implants, pacemakers, etc.); 2.Severe anxiety and depression due to various reasons (24 HAMD scores greater than 35, 14 HAMA scores greater than 29); 3.History of migraine prophylactic drug adjustment during screening and treatment; 4.aphasia and cognitive dysfunction (MMSE rating <=23); 5.Pregnancy or lactation; 6.Clinicians evaluate severe comorbidities that are not treatable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the average number of migraine days per month; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in the average number of migraine days per month;Migraine severity;Metabolomics;Changes of FMRI at rest state;Cytokines;Accompanying symptoms;Medication;Anxiety and depression;Intestinal flora;Migraine score,; | — |
Countries
China
Contacts
Public ContactFeng Zhiying
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed