schizophrenia
Conditions
Interventions
1-health control:NA
1-First-episode schizophrenia group:NA
1-First-episode depression group:NA
2- True stimulation group of schizophrenia accompanied by auditory hallucinations:rTMS true stimulation + drug treatment
2- Pseudo-stimulus group of schizophrenia accompanied by auditory hallucinations:rTMS pseudo-stimulation + drug therapy
Sponsors
Beijing Anding Medical Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 45 Years
Inclusion criteria
Inclusion criteria: Part One Study First-Episode Schizophrenia Patient Group Inclusion Criteria: 1. Aged 16-45 years, with at least a middle school education. 2. Right-handed, with normal vision and hearing, and no history of visual or auditory system diseases. 3. Meets the diagnostic criteria for schizophrenia according to DSM-V. 4. First episode of the illness, with a duration of illness = 5 years. 5. No prior systematic treatment with antipsychotic medications (continuous regular use = 1 month or irregular use = 3 months). First-Episode Depression Patient Group Inclusion Criteria: 1. Aged 16-45 years, with at least a middle school education. 2. Right-handed, with normal vision and hearing, and no history of visual or auditory system diseases. 3. Meets the diagnostic criteria for depressive disorders according to DSM-V, first episode. 4. No prior psychiatric medication treatment or unsystematic treatment (continuous regular use = 2 weeks). 5. Able to cooperate and complete various assessments. Healthy Control Group Inclusion Criteria: 1. Aged 16-45 years, with at least a middle school education. 2. Right-handed, with normal vision and hearing, and no history of visual or auditory system diseases. 3. Assessed using the MINI, not meeting any diagnostic criteria for mental disorders. Part Two Study Inclusion Criteria: 1. Aged 16-45 years, with at least a middle school education. 2. Right-handed, with no musical background. 3. Meets the diagnostic criteria for schizophrenia according to DSM-V. 4. Exhibits significant auditory hallucinations, with a PANSS scale score for hallucinations = 3, and symptoms have persisted for at least one month. 5. Maintains a stable dosage of antipsychotic medication one week prior to enrollment and throughout the study period. 6. Able to cooperate and complete the assessment and treatment protocols.
Exclusion criteria
Exclusion criteria: Part One: Study First-Episode Schizophrenia Patient Group Exclusion Criteria: 1. Currently or previously diagnosed with schizoaffective disorder, delusional disorder, bipolar disorder or depressive disorder, delirium, dementia, or other cognitive disorders, intellectual developmental disorder (IQ < 70), or mental disorders caused by physical diseases or psychoactive substances. 2. History of clearly diagnosed severe or unstable neurological and other physical diseases. 3. Individuals who are excited, impulsive, uncooperative, or who the researcher believes may exhibit suicidal or violent behavior during the study. 4. Received electroconvulsive therapy or electromagnetic stimulation treatment within the past six months. 5. History of alcohol and substance abuse or dependence. First-Episode Depression Patient Group Exclusion Criteria: 1. Meets the diagnostic criteria for other mental disorders according to DSM-V. 2. History of clearly diagnosed severe or unstable neurological and other physical diseases. 3. Individuals who are excited, impulsive, uncooperative, or who the researcher believes may exhibit suicidal or violent behavior during the study. 4. Received electroconvulsive therapy or electromagnetic stimulation treatment within the past six months. 5. History of alcohol and substance abuse or dependence. Healthy Control Group Exclusion Criteria: 1. A history of mental illness or family history of mental illness, and presence of intellectual developmental disorder (IQ < 70). 2. History of clearly diagnosed severe or unstable neurological and other chronic physical diseases. 3. History of alcohol and substance abuse or dependence. Part Two: Study Exclusion Criteria: 1. History of cranial disease, brain injury, seizures, or other neurological diseases. 2. Severe systemic diseases of the cardiovascular, respiratory, immune systems, etc. 3. History of alcohol or opioid drug abuse. 4. Individuals who are excited, impulsive, uncooperative, or who the researcher believes may exhibit suicidal or violent behavior during the study. 5. Currently having severe suicidal thoughts or behaviors. 6. Received physical treatments such as MECT or transcranial magnetic stimulation within the past six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy and sensitivity of individualized paradigms;Neuroelectrophysiological changes before and after treatment;Changes in brain imaging before and after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Auditory hallucination relief rate;The remission rate of psychotic symptoms;The score reduction rate of emotional changes before and after treatment; | — |
Countries
China
Contacts
Public ContactYanping Ren
Beijing Anding Medical Hospital, Capital Medical University
Outcome results
None listed